GASTRIC BOTOX AND BOTULISMS (BOTULISM)
Obesity is a serious health problem with an increasing prevalence all over the world. Studies continue on various surgical techniques, drug treatments and non-operative endoscopic methods to control obesity. According to our current scientific data, surgical interventions in the treatment of obesity remain as the most effective and long-term treatment method.
Botulinum toxin is a toxin created by Clostridium Botulinum bacteria that causes temporary relaxation in the muscles. It has long been used in strabismus, muscular dystonia and cosmetic applications in humans. It has been shown to be effective in achalasia and anal fissures in the gastrointestinal tract. It is thought that it can be used as aweight loss method in the field of obesity as it delays gastric emptying when applied to the stomach tissue.
In animal experiments, botox application has been shown to cause weight loss. When injected into the gastric tissue endoscopically, it has the effects of delaying gastric emptying and decreasing appetite. Conflicting results have beenobtained in human studies. There are publications stating that Botox application causes weight loss as well as publications stating that it is not effective. Weight loss alone has not been demonstrated. The weight loss rates obtained in some studies with Botox application are low and seem more dependent on the diet applied.
The fact that the procedure is relatively simple to apply, is reversible, does not require surgery, and has a very lowrate of side effects has increased the interest in this application. In general, no serious side effects are observed. However, as the number of applications increased, an increase in the number of complications began to be observed.
Regarding its use in non-obesity indications, it has been stated by the FDA that it may have side effects such as respiratory arrest and death. The doses made in stomach botox application vary between 100U and 500U. There is no consensus on the application area and technique to the stomach. Botulinum toxin is applied endoscopically to themuscle tissue of the stomach or under the mucous membrane. Administration in high doses may cause the toxin to enter the blood and systemic side effects may occur. It is also known that anatomically and technically incorrect applications can cause various complications. For this reason, it is recommended to be done by experienced people and under appropriate conditions.
Botulismus is a type of poisoning caused by the toxin produced by the bacteria Clostridium botulinum. In humans, it mostly occurs in the form of bacterial growth in cans that are not prepared under appropriate conditions and food poisoning due to the toxin produced by the bacteria.
It can also be seen after stomach botox application. A similar clinical picture may occur as a result of high-dose toxinadministration. After high doses or inappropriate injections, the toxin enters the systemic circulation and systemic effects are observed. The toxin causes muscle weakness and paralysis by affecting neuromuscular communication.
As a result of this;
*Blurred or double vision
*Difficulty on speaking and swallowing
*Decreased heart rate
*low blood pressure,
*difficulty on breathing
*weakness in muscles
*Unexpected skin color changes
*Nausea, vomiting and constipation
It is among the general symptoms. After gastric botox application in patients, a health institution should be consultedas soon as possible when these findings are observed. In treatment, antitoxin application and supportive treatments are performed.